ABSTRACT
Background: Islet cell-specific autoantibodies such as islet cell antibody (ICA), antiinsulin (IAA), anti-glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) can be present in patients with type I diabetes. Breast feeding duration and the early exposure to milk substitutes are environmental factors associated to etiology of type 1 diabetes. Aim To study the frequency of the anti-GAD, anti-IA-2 e ICA antibodies in Chilean type 1 diabetic patients and determine the possible modulator effect of the breast feeding. Patients and methods: One hundred thirty four type I diabetic patients, aged one to 15 years old, were studied at the moment of their diagnosis. Patients were classified according to the duration of exclusive breast feeding. IA-2 and GAD were determined by radio immuno assay and ICA by means of indirect immunofluorescence. Results: Subjects with three months or less and those with more than three months of breast feeding were positive for ICA in 78.8 and 90.6 per cent of cases respectively, for GAD in 75 and 54.6 per cent of cases respectively (p=0.024) and for IA-2 in 73 and 43.8 per cent of cases respectively (p=0.001). All three antibodies were positive in 53.9 and 21.8 per cent of children with less or more than three months of breast feeding (p=0.001). Conclusion: Both IA-2 and GAD antibodies are less frequently positive in type 1 diabetic patients who have been breast fed for more than three months. These findings suggest a possible attenuating role of exclusive breast feeding on pancreatic aggression events in patients with type 1 diabetes
Subject(s)
Humans , Child, Preschool , Infant , Child , Male , Female , Autoantibodies/immunology , Breast Feeding , Diabetes Mellitus, Type 1/immunology , Autoimmunity/immunology , Islets of Langerhans/immunology , Glutamic Acid/immunology , Insulin Antibodies/immunology , Protein Tyrosine Phosphatases/immunologyABSTRACT
Se estudia el pérfil nutricional de un grupo de 27 pacientes VIH(+) de las categorías A(17 casos) y B(10 casos) de la clasificación CDC a los cuales se les practicó una evaluación nutricional antropométrico y bioquímica así como el recuento de los linfocitos T-CD4(+). El trabajo permite demostrar un progresivo deterioro del estado nutricional
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Nutritional Status , Acquired Immunodeficiency Syndrome/complications , Anthropometry , CD4-Positive T-Lymphocytes , Biomarkers/blood , Nutrition Assessment , Disease Progression , Reference Values , Acquired Immunodeficiency Syndrome/immunology , Acquired Immunodeficiency Syndrome/metabolismABSTRACT
Las hiperlipidemias representan un conjunto de enfermedades caracterizadas por el aumento de las lipoproteínas circulantes y que se manifiestan por una elevación de la concentración plasmática del colesterol y/o de los triglicéridos. La base del tratamiento de estas alteraciones, radica en la dieta, la que debe ser formulada en forma correcta y adecuada, especialmente en aquellos pacientes en los que es el único elemento terapéutico. En esta revisión se analizan las recomendaciones dietéticas actuales, fijadas por los Comités de expertos americanos y europeos y se sugieren pautas de tratamiento